This position involves working as a member of the TIMI statistical group by leading statistical analysis projects from multiple international clinical trials. Qualified candidates are required to have a comprehensive understanding of biostatistics with particular expertise in design and analysis of clinical trial data. The incumbent will work closely with physician investigators and research fellows at the TIMI Study Group in designing and executing statistical analysis plans. The incumbent will also work closely with statistical colleagues to research appropriate and novel statistical methods as needed.
Research development and management
Possess a solid understanding of the purpose, objectives and goals of each trial and project.
Collaborate with physician investigators to develop statistical plans for investigational protocols and manuscripts.
Collaborate with the physician investigators with the preparation of manuscripts, abstracts, and presentations at scientific meetings.
Research and develop new analytic techniques as needed.
Provide continuing education for statisticians and programmers within the statistical group, as well as to the TIMI physician investigators.
Determine and/or verify correct statistical testing to be performed in each analysis request.
Performs or oversees statistical testing as appropriate.
Create graphical displays of data as appropriate for specific projects.
Oversee the compilation and organization of data analyses for transmission to investigators, sponsors, or the Director.
Assure the maintenance of an up to date electronic archive recording data requests, statistical testing, and data transmissions performed.
Perform other duties as required and as appropriate.
Effectively interact with other members of the organization to reach the pre-specified goals of each trial and project.
Performs other duties as required and as appropriate.
MS/MPH in biostatistics or a related field with a minimum of five years experience or PhD in biostatistics or related field with a minimum of 1-2 years experience with data analysis and programming in a clinical trials setting such as pharmaceutical or CRO.
Experience with survival analysis is required.
Ability to work independently as well as part of a team
Possess managerial skills in order to interact with both with statistical personnel, physician investigators and other members of the research group.
Possess strong analytical skills
Ability to prioritize assignments, multi-task, make decisions based upon sound principles, and independently problem solve.
Ability to draft plans to resolve inaccuracies or other problematic situations.
Ability to make decisions related to issues in the statistical group pending final approval from the Director.
Ability to develop novel ways to coordinate, manage and report data if required by new trials.
Demonstrated sound independent judgment and competencies in clinical research.
Additional Salary Information: Salary to be determined and commensurate with experience.
About Brigham and Women's Hospital, TIMI Study Group
The TIMI Study Group is an academic research organization at Brigham and Women's Hospital, Department of Cardiovascular Medicine.
Since its inception in 1984, the principal goal of the TIMI Study Group has been to conduct high quality
clinical trials that enhance the care of patients suffering from cardiovascular disease and its risk factors.
TIMI has led a wide array of phase 1 to phase 4 trials, as well as registries. These have ranged in size
from less than 30 to more than 25,000 subjects. The interventions studied include fibrinolytic,
antithrombotic, anti-platelet, anti-ischemic, lipid lowering, anti-inflammatory, and anti-diabetic agents as
well as percutaneous coronary intervention. In addition, the TIMI Study Group has used its growing
database of more than 300,000 subjects and their clinical findings, electrocardiograms, angiograms,
biomarkers, and genotypes to enhance the understanding of cardiovascular disease and its risk
factors. An important corollary goal has been to train the next generation of clinical investigators. TIMI is
especially proud of these trainees who have assumed leadership positions in leading institutions
around the world.